Mission vs. Nob Hill - New from London - HELP!!

Hey, so I have moved from London to San Francisco and am apartment hunting. I have seen a few properties and two are my faves. One is 1600 15th Street (Mission) and the other is Nob Hill (899 Pine Street). I want a location that is fun and close to bars/restaurants but also safe and clean etc. Also I commute between the City and Sunnyvale so ease for both. Any help would be greatly appreciated!
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