100 Ave, Clinton / Hells Kitchen

10th Avenue starts at 59th street (it turns into Amsterdam north of 60th). 10th is not the most desirable Avenue in NY for a number of reasons. It's pretty desolate, far from transportation and there aren't the most attractive buildings in these parts.
St Luke's Hospital is on the corner of 59th and 10th Avenue which doesn't seem noteworthy but seeing as St. Vincent's just closed, it's always good to know where a hospital on the west side is, in my opinion. And, there's actually one really pretty stretch of land at around 47th and 10th due to Eden Farm. It was developed by the Astor Family and has a bunch of brownstones that still remain. The block is really pretty and especially attractive considering it abuts tenement looking buildings that line most of Hell's Kitchen. There are a few little restaurants on 10th around this block to cater to the residents, but I don't really go to Hell's Kitchen so I can't say I have patronized any of them.
10th at 43rd houses a really interesting building: Manhattan Plaza. It is a really nice building that houses only performing artists and caters to each tenant's specific income. It's a really cool idea but the wait list is upwards of five years, so most people either give up or actually have money by the time they can get in.
Lincoln Tunnel is on 10th at 47th street and that sounds like a boring fact but I lived here for a while before I figured out where that was; and, you kind of need it if you plan on leaving Manhattan. The bummer of Lincoln tunnel is that it makes traffic unbearable around this area because of all of the commuters.
There is a restaurant on 10th at 27th called Bongo that serves pretty good oysters. It's the only restaurant I have eaten at on 10th avenue and I was pretty happy with it. . . . although I probably won't go back simply because of the area. There's really not much around here, so it seems like a schlep even if it's equidistance from your house to another oyster bar. Cookshop is another really renowned restaurant on 10th and that seems to always be busy which leads me to believe that 10th won't be no mans land within the next five years. But, that's the thing about New York. . . there's always a new hot street or hot neighborhood.