I agree with Brian. I also don't recommend going on Friday afternoon, either. Mid-week and mid-day are the best times to hit up any of the DMV (thought we call them BMV) locations.
It depends on the location you choose. The Bureau of Motor Vehicles has a number of Cincinnati based Deputy Registrars: http://www.bmv.ohio.gov/31.stm
They also have a regional office in Mount Healthy. If you choose a not-so busy location on a not-so busy day, you can narrow the wait time. Check before you go though. Not all of the registrars offer all BMV services.