Chicago Loop - Dangerous to the south?

It's fine, just depends how far south you go. Chicago get's such a bad wrap these days, some parts of the city are known for their homeless and drug problems. I would say dont go too far south of the loop, once you get to Chinatown unless you know what you are doing I would not go alone or too late at night.

no matter where you are be aware of your surroundings. The south side has really awesome areas and shady ones...