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Acetaminophen has been as s ociated with cas es of acute liver failure, at times res ulting in liver trans plant and death. Mos t of the cas es of liver injury are as s ociated with the us e of acetaminophen at dos es that exceed 4,000 milligrams per day, and often involve more than one acetaminophen-containing product [see WARNINGS, OVERDOSE].

Risks from Concomitant Use with Benzodiazepines or Other CNS Depressants
Concomitant use of opioids with benzodiazepines or other central nervous system (CNS) depressants , including alcohol, may result in profound sedation, respiratory depression, coma, and death [see WARNINGS, DRUG INTERACTIONS].

Reserve concomitant prescribing of hydrocodonebitartrate and acetaminophen tablets and benzodiazepines or other CNS depressants for use in patients for whom alternative treatment options are inadequate.
Limit dosages and durations to the minimum required.
Follow patients for signs and symptoms of respiratory depression and sedation
DESCRIPTION
Hydrocodone bitartrate and acetaminophen are available in tablet form for oral administration.

Hydrocodone bitartrate is an opioid analgesic and occurs as fine, white crystals or as a crystalline powder. It is affected by light. The chemical name is 4,5-epoxy-3-methoxy-17-methylmorphinan-6-one tartrate (1:1) hydrate (2:5). It has the following structural formula:
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