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The potential dangers of oxycodone can be traced as far back as the 1960's when the United Nations Office on Drugs and Crime classified it as a dangerous drug as part of The Dangerous Drugs (Amendment) Ordinance, 1960.10 Abuse in the United States has been a continuing problem since the early 1960's, prompting the United States Government to classify it as a Schedule II drug. Until 1995, when the Food and Drug Administration approved OxyContin there was little concern over the abuse of oxycodone producers. But, in 1996 when the manufacturer of OxyContin began to market and distribute the drug, concerns and reports of illicit use and abuse began to increase.11 At first, drug abuse treatment centers, law enforcement personnel, and pharmacists in Maine, Virginia, West Virginia, Ohio, Kentucky, and Maryland reported increases in the abuse of OxyContin. Now, abuse of the drug has expanded throughout the United States.12
Oxycodone products can be administered intramuscularly (injection directly into the muscle), intravenously (injection into the blood stream), subcutaneously (injection under the skin), rectally, and/or orally through pills and tablets.13 OxyContin, (in tablet form) taken orally, can remain effective for up to 12 hours, making it the longest acting oxycodone product available. While legal doses vary by patient, a typical dose prescribed by a physician ranges from two to four tablets daily. Currently there are four dosages available - 10, 20, 40, and 80mg tablets. The 160mg tablet (available in 2000) was suspended in May 2001 due to its severe abuse potential.14 Those who abuse the drug generally do so in three different ways: crushing the pill into a fine powder and snorting it; chewing it; or crushing and dissolving the tablets in water and injecting the solution. Many of these methods are primarily used with OxyContin in order to defeat the time-release mechanism of the drug, causing the active ingredient to take effect almost immediately after ingestion. When using OxyContin this way, the risk of an overdose increases dramatically since the drug is not intended to be used in this manner. Some users also mix the drug with alcohol to achieve an even greater high,15 even though it can be a fatal combination.