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Hydrocodone exerts its principle pharmacological effects
through agonistic binding to opioid receptors. Hydrocodone
primarily binds and activates the mu-opioid receptor in the
CNS and possesses analgesic and antitussive effects. Binding
of hydrocodone to this receptor also results in analgesia,
euphoria, respiratory depression, decreased gastrointestinal
motility and physical dependence. Additionally, hydrocodone
is converted to hydromorphone by the cytochrome P 450
Hydrocodone is abused for its opioid effects. Widespread
diversion via bogus call-in prescriptions, altered prescriptions,
theft, and illicit purchases from Internet sources are made
easier by the present controls placed on hydrocodone
products. Hydrocodone pills are the most frequently
encountered dosage form in illicit traffic. Hydrocodone is
generally abused orally, often in combination with alcohol.
Of particular concern is the prevalence of illicit use of
hydrocodone among school-aged children. The 2016
Monitoring the Future Survey reports that 0.8%, 1.7% and
2.9% of 8th, 10th, and 12th graders, respectively, used Vicodin
for nonmedical purposes in the past year.