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(Trade Names: Vicodin
Since 2009, hydrocodone has been the second most
frequently encountered opioid pharmaceutical in drug evidence
submitted to federal, state, and local forensic laboratories as
reported by DEAs National Forensic Laboratory Information
System (NFLIS) and System to Retrieve Information from Drug
Evidence (STRIDE)/STARLiMS databases.
Hydrocodone is an antitussive (cough suppressant) and
narcotic analgesic agent for the treatment of moderate to
moderately severe pain. Studies indicate that hydrocodone is
as effective, or more effective, than codeine for cough
suppression and nearly equipotent to morphine for pain relief.
Hydrocodone is the most frequently prescribed opiate in
the United States with more than 136.7 million prescriptions for
hydrocodone-containing products dispensed in 2013 and with
93.7 million and 83.6 million dispensed recently in 2016 and
2017, respectively (IMS Health). There are several hundred
brand name and generic hydrocodone products marketed,
most of which are combination products. The most frequently
prescribed combination is hydrocodone and acetaminophen
Chemistry and Pharmacology
Hydrocodone [4,5-epoxy-3-methoxy-17-methylmorphinan-6-one tartrate (1:1) hydrate (2:5),
dihydrocodeinone] Hydrocodone [4,5-epoxy-3-methoxy-17-
methyl-morphinan-6-one tartrate (1:1) hydrate (2:5),
dihydrocodeinone] is a semi-synthetic opioid most closely
related to codeine in structure and morphine in producing
opiate-like effects. The first report, that hydrocodone produces
euphoria and habituation symptoms, was published in 1923.
The first report of hydrocodone dependence and addiction was
published in 1961.