There are a lot of choices in Mission Dolores, San Francisco when it comes to fitness center recommendations-- including a 24-fitness on Market and J & K on Mission. I personally would go for Valencia Street Muscle that's were I really tone my abs--no, just kidding (that is a total meathead place). Core Pilates on 17th is the best--good place to go and not get bothered if you're a single gal.
If you're looking for a boyfriend, try 24 Hour, I hear that is a total meat market despite its proximity to Castro.