To be honest, I'm not a fan of the bars in the DePaul area. If you are over 22, you'll be the old person in the bar and probably not have a great time. There are a lot of "pubs" that are actually just bars that play generic music really loud, there's dancing, generic beer selections...you get the picture. It's not my cup of tea, but a TON of people go out in the area, so a lot of people would say the opposite. There are 2 blues clubs in the neighborhood - B.L.U.E.S. and Kingston Mines - that are better options. BUT, these places are very touristy and not much like an actual neighborhood blues club like you'll find on the South Side.