Where is the best pizza in Castro District, San Francisco?

Because a persons sense of safety is such a personal thing, I think the best answer to your question is to know where to look for data that can help you make your decision. The Castro District is covered by the Mission Street Police Department (http://sf-police.org/index.aspx?page=819). They have great community outreach and are really focused on prevention and do a great job with crime investigation when it does happen. Living in a busy urban area always has it's challenges, and SF and the Castro are no exception There's a great website I use with clients to help them get educated on crime and safety, as well connecting them to public resources that have statistics, teach self-defense, educate on personal safety and help people get involved with neighborhood watches and action groups (http://sanfrancisco.crimespotting.org/). Check these resources out and make your mind up what's safe for you!

Best pizza, hands down, in the neighborhood, and the city as far as I'm concerned, is Marcello's at 420 Castro Street. It's fresh, the staff and owner "Luke" are really friendly, and you can sit in the windows while you enjoy your slice and watch life if the Castro pass you by!