"Kind of seedy, but close to the nightlife and cultural centers"
Despite being near the Setai Hotel in Miami Beach, a luxurious establishment, 21st Street can be dangerous at times if you are not careful. On the plus side, it has metered parking with beach access, which belongs to the Days Inn hotel, but anyone can park there because it is a public lot. There is a fabulous little dive bar across the parking lot, as well as some more expensive clubs around the corner, so it's a good location for those who want a taste of South Beach without paying too much for admission and drinks. The Bass Museum of Art is also nearby, as well as the public library. However, once you cross Collins Avenue, the other side of 21st Street has some undesirable neighborhoods that locals usually avoid. This are has been known for its crime and not the best place to walk at night if you are unfamiliar with the area. Fortunately, this area also spans only a few blocks. Once you reach the other end of 21st Street, you reach the Convention Center on Washington Avenue and you will be once again near other great places, such as the Fillmore Theater, where you can catch a musical performance or a ballet. Overall, the area is great- lots of things to do, places to go. However, the moral of my story is just be careful when walking around the residential areas around 21st Street, so your lovely night out doesn't end up being unnecessarily unpleasant.